Further studies of inhibition of bacterial glutamic decarboxylase.

In a previous communication experiments were described in which several substances structurally related to glutamic acid were tested for the inhibition of utilization of glutamic acid by Lactobacillus arabinosus (1). In the present communication these substances, together with a number of others, were tested for their inhibition of bacterial glutamic decarboxylase. The mechanisms of action of ac-oximinoglutaric acid and a-methyl-nn-glutamic acid, the most potent inhibitors, were elucidated.